ISCA1 is a mitochondrial protein involved in the biogenesis and assembly of iron-sulfur clusters, which play a role in electron-transfer reactions (Cozar-Castellano et al., 2004 [PubMed 15262227]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for ISCA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ISCA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ISCA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:86,098,791–86,100,295 | 183.0 kb | Distal (>10kb) Multiome | 436 | |
| chr9:86,118,248–86,119,118 | 164.0 kb | Distal (>10kb) Multiome | 10 | |
| chr9:86,126,993–86,127,913 | 155.0 kb | Distal (>10kb) Multiome | 439 | |
| chr9:86,186,986–86,187,492 | 95.3 kb | Distal (>10kb) Multiome | 90 | |
| chr9:86,281,630–86,283,173 | 1 bp | At TSS Multiome | 959 | |
| chr9:86,287,090–86,287,275 | 5.0 kb | Proximal (<10kb) | 192 | |
| chr9:86,353,702–86,354,978 | 72.0 kb | Distal (>10kb) Multiome | 1008 | |
| chr9:86,491,030–86,491,730 | 209.0 kb | Distal (>10kb) Multiome | 79 |
Genomic view of the ISCA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.