IRF2BPL

interferon regulatory factor 2 binding protein like | EAP1, KIAA1865, C14orf4

This gene encodes a transcription factor that may play a role in regulating female reproductive function. [provided by RefSeq, Jun 2012]

Member of: DE-9 Developmental clusters: GC3

Biological processes 15 terms

development of secondary female sexual characteristics (GO:0046543)extracellular region (GO:0005576)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)nervous system development (GO:0007399)nuclear body (GO:0016604)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein ubiquitination (GO:0016567)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)

Expression (TPM)

TFs regulating IRF2BPL 0 TFs

Transcription factors with Perturb-seq knockdown data for IRF2BPL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IRF2BPL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to IRF2BPL

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IRF2BPL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr14:76,761,176–76,762,367	267.0 kb	Distal (>10kb) Multiome	486
chr14:76,784,691–76,785,144	243.7 kb	Distal (>10kb) Multiome	318
chr14:76,812,161–76,813,291	215.8 kb	Distal (>10kb) Multiome	878
chr14:76,913,323–76,913,886	115.0 kb	Distal (>10kb) Multiome HiCAR	352
chr14:76,924,332–76,925,072	104.0 kb	Distal (>10kb) Multiome HiCAR	256
chr14:76,947,024–76,947,904	81.3 kb	Distal (>10kb) Multiome HiCAR	690
chr14:76,955,827–76,957,395	72.1 kb	Distal (>10kb) Multiome HiCAR	873
chr14:76,961,044–76,962,678	66.8 kb	Distal (>10kb) Multiome	848
chr14:76,968,574–76,969,080	59.8 kb	Distal (>10kb) Multiome HiCAR	311
chr14:76,987,872–76,988,397	40.6 kb	Distal (>10kb) Multiome	38
chr14:77,024,027–77,024,710	4.3 kb	Proximal (<10kb) Multiome	368
chr14:77,025,547–77,029,182	57 bp	At TSS Multiome	996
chr14:77,029,256–77,029,523	548 bp	At TSS	251
chr14:77,032,573–77,034,628	5.3 kb	Proximal (<10kb) Multiome	917
chr14:77,040,063–77,040,913	11.8 kb	Distal (>10kb) Multiome	765
chr14:77,085,220–77,085,934	56.9 kb	Distal (>10kb) Multiome	132
chr14:77,088,297–77,088,792	59.7 kb	Distal (>10kb) Multiome	234
chr14:77,097,312–77,099,236	69.4 kb	Distal (>10kb) Multiome	948
chr14:77,124,505–77,125,759	96.3 kb	Distal (>10kb) Multiome	289
chr14:77,139,459–77,142,559	111.1 kb	Distal (>10kb) Multiome	507
chr14:77,181,185–77,182,207	153.0 kb	Distal (>10kb) Multiome	485
chr14:77,270,588–77,271,586	242.4 kb	Distal (>10kb) Multiome	147
chr14:77,320,198–77,322,121	292.4 kb	Distal (>10kb) Multiome	915

Genome Browser

Genomic view of the IRF2BPL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.