The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for IPO7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IPO7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IPO7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:9,090,882–9,091,926 | 293.2 kb | Distal (>10kb) Multiome | 196 | |
| chr11:9,264,697–9,266,230 | 119.2 kb | Distal (>10kb) Multiome | 703 | |
| chr11:9,313,980–9,315,407 | 69.9 kb | Distal (>10kb) Multiome | 997 | |
| chr11:9,318,649–9,319,624 | 65.4 kb | Distal (>10kb) Multiome | 258 | |
| chr11:9,363,967–9,364,851 | 20.1 kb | Distal (>10kb) Multiome | 1019 | |
| chr11:9,384,450–9,385,531 | 26 bp | At TSS Multiome | 939 | |
| chr11:9,460,209–9,461,643 | 76.2 kb | Distal (>10kb) Multiome | 1040 | |
| chr11:9,572,794–9,575,580 | 190.7 kb | Distal (>10kb) Multiome | 1075 | |
| chr11:9,613,193–9,614,617 | 229.5 kb | Distal (>10kb) Multiome | 997 | |
| chr11:9,626,920–9,627,395 | 242.5 kb | Distal (>10kb) Multiome | 172 | |
| chr11:9,663,540–9,664,862 | 279.5 kb | Distal (>10kb) Multiome | 597 | |
| chr11:10,792,316–10,792,962 | 1408.0 kb | Distal (>10kb) Multiome HiCAR | 530 |
Genomic view of the IPO7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.