DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and is located in the critical region of loss of heterozygosity (LOH). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2015]
Transcription factors with Perturb-seq knockdown data for INTS6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = INTS6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of INTS6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:51,169,207–51,170,289 | 283.1 kb | Distal (>10kb) Multiome | 174 | |
| chr13:51,221,124–51,223,194 | 230.9 kb | Distal (>10kb) Multiome | 488 | |
| chr13:51,243,717–51,244,186 | 209.1 kb | Distal (>10kb) Multiome | 185 | |
| chr13:51,244,496–51,245,455 | 207.8 kb | Distal (>10kb) Multiome | 117 | |
| chr13:51,303,027–51,303,676 | 149.8 kb | Distal (>10kb) Multiome | 130 | |
| chr13:51,451,249–51,454,202 | 1.3 kb | Proximal (<10kb) Multiome | 1037 | |
| chr13:51,583,370–51,585,461 | 131.1 kb | Distal (>10kb) Multiome | 1008 | |
| chr13:51,795,081–51,795,749 | 342.5 kb | Distal (>10kb) Multiome HiCAR | 50 | |
| chr13:51,803,129–51,804,466 | 350.9 kb | Distal (>10kb) Multiome HiCAR | 844 |
Genomic view of the INTS6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.