The Integrator complex is a complex that associates with the C-terminal domain of RNA polymerase II large subunit. This complex is brought to U1 and U2 small nuclear RNA genes, where it is involved in the transcription and processing of their transcripts. The protein encoded by this gene represents a subunit of the Integrator complex. [provided by RefSeq, Aug 2016]
Transcription factors with Perturb-seq knockdown data for INTS5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = INTS5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of INTS5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:62,382,190–62,383,008 | 270.7 kb | Distal (>10kb) Multiome | 36 | |
| chr11:62,460,403–62,461,004 | 192.5 kb | Distal (>10kb) Multiome | 20 | |
| chr11:62,508,289–62,508,878 | 144.7 kb | Distal (>10kb) Multiome | 499 | |
| chr11:62,542,658–62,543,488 | 110.3 kb | Distal (>10kb) Multiome | 537 | |
| chr11:62,545,051–62,547,562 | 106.3 kb | Distal (>10kb) Multiome | 889 | |
| chr11:62,553,213–62,553,741 | 99.9 kb | Distal (>10kb) Multiome | 489 | |
| chr11:62,555,905–62,556,742 | 97.0 kb | Distal (>10kb) Multiome | 545 | |
| chr11:62,560,588–62,561,104 | 92.6 kb | Distal (>10kb) Multiome | 541 | |
| chr11:62,561,760–62,562,358 | 91.3 kb | Distal (>10kb) Multiome | 43 | |
| chr11:62,573,347–62,574,645 | 79.3 kb | Distal (>10kb) Multiome | 845 | |
| chr11:62,591,246–62,592,462 | 61.6 kb | Distal (>10kb) Multiome | 976 | |
| chr11:62,600,988–62,603,291 | 51.4 kb | Distal (>10kb) Multiome | 872 | |
| chr11:62,611,665–62,613,544 | 40.4 kb | Distal (>10kb) Multiome | 737 | |
| chr11:62,621,550–62,622,445 | 31.2 kb | Distal (>10kb) Multiome | 964 | |
| chr11:62,646,025–62,647,031 | 6.6 kb | Proximal (<10kb) Multiome | 815 | |
| chr11:62,652,836–62,653,744 | 58 bp | At TSS Multiome | 921 | |
| chr11:62,664,567–62,666,291 | 11.9 kb | Distal (>10kb) Multiome | 1020 | |
| chr11:62,671,328–62,672,522 | 18.5 kb | Distal (>10kb) Multiome | 882 | |
| chr11:62,705,543–62,707,930 | 53.0 kb | Distal (>10kb) Multiome | 760 | |
| chr11:62,708,691–62,710,293 | 56.3 kb | Distal (>10kb) Multiome | 531 | |
| chr11:62,726,557–62,728,947 | 74.3 kb | Distal (>10kb) Multiome | 1088 | |
| chr11:62,753,347–62,754,665 | 100.8 kb | Distal (>10kb) Multiome | 696 | |
| chr11:62,761,085–62,762,045 | 108.2 kb | Distal (>10kb) Multiome | 649 | |
| chr11:62,770,753–62,772,068 | 118.1 kb | Distal (>10kb) Multiome | 885 | |
| chr11:62,786,365–62,787,860 | 133.3 kb | Distal (>10kb) Multiome | 1073 | |
| chr11:62,791,569–62,792,385 | 138.7 kb | Distal (>10kb) Multiome | 805 | |
| chr11:62,804,451–62,807,080 | 152.2 kb | Distal (>10kb) Multiome | 994 | |
| chr11:62,831,037–62,832,904 | 178.7 kb | Distal (>10kb) Multiome | 870 | |
| chr11:62,839,042–62,842,743 | 188.1 kb | Distal (>10kb) Multiome | 1403 | |
| chr11:62,851,028–62,851,955 | 198.2 kb | Distal (>10kb) Multiome | 421 | |
| chr11:62,855,209–62,856,560 | 202.7 kb | Distal (>10kb) Multiome | 1071 | |
| chr11:62,862,252–62,862,948 | 209.4 kb | Distal (>10kb) Multiome | 360 | |
| chr11:62,880,343–62,881,977 | 227.6 kb | Distal (>10kb) Multiome | 1080 | |
| chr11:62,909,033–62,909,985 | 256.1 kb | Distal (>10kb) Multiome | 366 |
Genomic view of the INTS5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.