Transcription factors with Perturb-seq knockdown data for INO80D-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = INO80D-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of INO80D-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:205,885,461–205,885,910 | 198.8 kb | Distal (>10kb) Multiome | 447 | |
| chr2:206,032,139–206,032,814 | 52.2 kb | Distal (>10kb) Multiome | 47 | |
| chr2:206,079,507–206,080,446 | 4.7 kb | Proximal (<10kb) Multiome | 153 | |
| chr2:206,082,237–206,082,708 | 2.2 kb | Proximal (<10kb) Multiome | 71 | |
| chr2:206,083,576–206,086,328 | 1.4 kb | Proximal (<10kb) Multiome | 990 | |
| chr2:206,158,932–206,160,379 | 75.0 kb | Distal (>10kb) Multiome | 968 | |
| chr2:206,212,416–206,212,901 | 128.0 kb | Distal (>10kb) Multiome | 120 | |
| chr2:206,274,456–206,275,776 | 190.2 kb | Distal (>10kb) Multiome | 641 |
Genomic view of the INO80D-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.