The protein encoded by this gene is a subunit of single-stranded DNA binding complexes that are important for maintaining genome stability. These complexes are involved in G2/M checkpoint control and homologous recombination repair. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for INIP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = INIP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of INIP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:112,097,640–112,098,616 | 619.8 kb | Distal (>10kb) Multiome HiCAR | 337 | |
| chr9:112,379,308–112,380,565 | 338.1 kb | Distal (>10kb) Multiome HiCAR | 895 | |
| chr9:112,486,079–112,487,780 | 231.3 kb | Distal (>10kb) Multiome | 1004 | |
| chr9:112,717,577–112,718,753 | 80 bp | At TSS Multiome | 751 | |
| chr9:112,750,159–112,751,980 | 32.6 kb | Distal (>10kb) Multiome | 907 | |
| chr9:112,771,981–112,772,634 | 54.2 kb | Distal (>10kb) Multiome | 89 | |
| chr9:113,011,893–113,012,348 | 294.1 kb | Distal (>10kb) Multiome | 444 |
Genomic view of the INIP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.