This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Transcription factors with Perturb-seq knockdown data for ILK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ILK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ILK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:6,318,947–6,321,304 | 283.7 kb | Distal (>10kb) Multiome | 591 | |
| chr11:6,353,367–6,353,932 | 250.2 kb | Distal (>10kb) Multiome | 395 | |
| chr11:6,367,341–6,367,799 | 236.2 kb | Distal (>10kb) Multiome | 55 | |
| chr11:6,389,605–6,390,990 | 213.4 kb | Distal (>10kb) Multiome | 752 | |
| chr11:6,405,086–6,405,670 | 198.4 kb | Distal (>10kb) Multiome | 99 | |
| chr11:6,418,399–6,419,618 | 184.7 kb | Distal (>10kb) Multiome | 494 | |
| chr11:6,468,896–6,469,642 | 134.5 kb | Distal (>10kb) Multiome | 253 | |
| chr11:6,473,129–6,474,612 | 129.7 kb | Distal (>10kb) Multiome | 591 | |
| chr11:6,480,885–6,482,114 | 122.4 kb | Distal (>10kb) Multiome | 828 | |
| chr11:6,496,967–6,497,550 | 106.5 kb | Distal (>10kb) Multiome | 71 | |
| chr11:6,586,489–6,587,591 | 16.8 kb | Distal (>10kb) Multiome | 231 | |
| chr11:6,603,192–6,604,726 | 28 bp | At TSS Multiome | 908 | |
| chr11:6,606,600–6,607,433 | 3.3 kb | Proximal (<10kb) Multiome | 532 | |
| chr11:6,611,505–6,613,097 | 8.6 kb | Proximal (<10kb) Multiome | 996 | |
| chr11:6,618,753–6,619,738 | 15.7 kb | Distal (>10kb) Multiome | 587 | |
| chr11:6,629,672–6,631,067 | 26.7 kb | Distal (>10kb) Multiome | 226 | |
| chr11:6,655,068–6,656,298 | 52.0 kb | Distal (>10kb) Multiome | 314 | |
| chr11:6,682,693–6,683,793 | 79.7 kb | Distal (>10kb) Multiome | 950 |
Genomic view of the ILK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.