Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]
Transcription factors with Perturb-seq knockdown data for IKZF4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IKZF4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IKZF4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:55,707,276–55,708,500 | 299.7 kb | Distal (>10kb) Multiome | 372 | |
| chr12:55,715,733–55,716,775 | 291.4 kb | Distal (>10kb) Multiome | 929 | |
| chr12:55,727,952–55,730,453 | 278.0 kb | Distal (>10kb) Multiome | 895 | |
| chr12:55,736,969–55,737,781 | 270.4 kb | Distal (>10kb) Multiome | 496 | |
| chr12:55,737,830–55,739,085 | 269.1 kb | Distal (>10kb) Multiome | 475 | |
| chr12:55,742,540–55,744,252 | 264.5 kb | Distal (>10kb) Multiome | 631 | |
| chr12:55,745,091–55,746,361 | 261.8 kb | Distal (>10kb) Multiome | 299 | |
| chr12:55,817,254–55,818,558 | 189.8 kb | Distal (>10kb) Multiome | 749 | |
| chr12:55,829,008–55,831,505 | 178.0 kb | Distal (>10kb) Multiome | 921 | |
| chr12:55,926,651–55,928,471 | 80.7 kb | Distal (>10kb) Multiome | 993 | |
| chr12:55,931,904–55,932,439 | 75.5 kb | Distal (>10kb) Multiome | 279 | |
| chr12:55,940,073–55,940,746 | 67.2 kb | Distal (>10kb) Multiome | 478 | |
| chr12:55,966,006–55,967,470 | 40.9 kb | Distal (>10kb) Multiome | 615 | |
| chr12:55,973,347–55,974,716 | 33.8 kb | Distal (>10kb) Multiome | 966 | |
| chr12:55,996,814–55,997,861 | 10.4 kb | Distal (>10kb) Multiome | 680 | |
| chr12:55,999,651–56,000,093 | 7.6 kb | Proximal (<10kb) | 19 | |
| chr12:56,006,888–56,008,461 | 38 bp | At TSS Multiome | 745 | |
| chr12:56,020,644–56,021,511 | 13.3 kb | Distal (>10kb) Multiome | 364 | |
| chr12:56,041,220–56,042,537 | 34.1 kb | Distal (>10kb) Multiome | 1035 | |
| chr12:56,078,964–56,081,015 | 71.6 kb | Distal (>10kb) Multiome | 1032 | |
| chr12:56,103,918–56,105,302 | 96.7 kb | Distal (>10kb) Multiome | 977 | |
| chr12:56,115,844–56,117,060 | 108.9 kb | Distal (>10kb) Multiome | 958 | |
| chr12:56,117,641–56,119,301 | 110.5 kb | Distal (>10kb) Multiome | 1052 | |
| chr12:56,126,181–56,126,640 | 118.7 kb | Distal (>10kb) Multiome | 671 | |
| chr12:56,127,552–56,129,104 | 120.5 kb | Distal (>10kb) Multiome | 800 | |
| chr12:56,151,724–56,153,003 | 144.8 kb | Distal (>10kb) Multiome | 830 | |
| chr12:56,157,307–56,159,499 | 150.6 kb | Distal (>10kb) Multiome | 1008 | |
| chr12:56,188,836–56,190,865 | 181.9 kb | Distal (>10kb) Multiome | 954 | |
| chr12:56,221,094–56,222,691 | 214.3 kb | Distal (>10kb) Multiome | 884 | |
| chr12:56,222,996–56,223,487 | 215.5 kb | Distal (>10kb) Multiome | 38 | |
| chr12:56,223,843–56,224,800 | 216.7 kb | Distal (>10kb) Multiome | 765 | |
| chr12:56,257,471–56,258,774 | 250.8 kb | Distal (>10kb) Multiome | 710 | |
| chr12:56,266,608–56,267,683 | 259.4 kb | Distal (>10kb) Multiome | 857 | |
| chr12:56,299,744–56,300,865 | 292.8 kb | Distal (>10kb) Multiome | 923 |
Genomic view of the IKZF4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.