Predicted to enable kinase binding activity. Predicted to be involved in synaptic membrane adhesion. Predicted to act upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules and positive regulation of inhibitory postsynaptic potential. Predicted to be located in dendrite; inhibitory synapse; and neuronal cell body. Predicted to be active in GABA-ergic synapse; neuron projection; and postsynaptic specialization of symmetric synapse. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for IGSF9B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IGSF9B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IGSF9B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:133,657,067–133,657,724 | 299.6 kb | Distal (>10kb) Multiome | 77 | |
| chr11:133,787,506–133,788,183 | 169.1 kb | Distal (>10kb) Multiome | 187 | |
| chr11:133,854,269–133,855,200 | 102.3 kb | Distal (>10kb) Multiome | 98 | |
| chr11:133,947,207–133,947,600 | 9.6 kb | Proximal (<10kb) Multiome | 204 | |
| chr11:133,951,064–133,952,093 | 5.4 kb | Proximal (<10kb) Multiome | 268 | |
| chr11:133,955,545–133,957,834 | 101 bp | At TSS Multiome | 423 | |
| chr11:134,033,701–134,034,640 | 77.2 kb | Distal (>10kb) Multiome | 251 | |
| chr11:134,036,538–134,037,918 | 80.3 kb | Distal (>10kb) Multiome | 381 | |
| chr11:134,068,849–134,069,824 | 112.1 kb | Distal (>10kb) Multiome | 407 | |
| chr11:134,223,679–134,225,624 | 267.6 kb | Distal (>10kb) Multiome | 944 | |
| chr11:134,252,809–134,254,050 | 296.5 kb | Distal (>10kb) Multiome | 758 |
Genomic view of the IGSF9B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.