Predicted to enable insulin-like growth factor binding activity. Involved in cellular response to tumor cell. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for IGFBPL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IGFBPL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IGFBPL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:37,913,669–37,914,191 | 510.6 kb | Distal (>10kb) Multiome HiCAR | 509 | |
| chr9:38,154,485–38,155,231 | 269.6 kb | Distal (>10kb) Multiome | 80 | |
| chr9:38,214,046–38,215,198 | 209.7 kb | Distal (>10kb) Multiome | 249 | |
| chr9:38,226,445–38,227,547 | 197.4 kb | Distal (>10kb) Multiome | 478 | |
| chr9:38,380,130–38,381,754 | 43.5 kb | Distal (>10kb) Multiome | 696 | |
| chr9:38,392,279–38,393,206 | 31.8 kb | Distal (>10kb) Multiome | 749 | |
| chr9:38,417,066–38,417,317 | 7.1 kb | Proximal (<10kb) | 88 | |
| chr9:38,423,581–38,424,783 | 114 bp | At TSS Multiome | 342 | |
| chr9:38,427,089–38,427,935 | 3.1 kb | Proximal (<10kb) Multiome | 164 | |
| chr9:38,432,999–38,433,174 | 8.5 kb | Proximal (<10kb) | 77 | |
| chr9:38,433,915–38,434,850 | 10.0 kb | Distal (>10kb) Multiome | 31 | |
| chr9:38,619,665–38,622,690 | 196.3 kb | Distal (>10kb) Multiome | 761 | |
| chr9:38,672,308–38,672,940 | 248.2 kb | Distal (>10kb) Multiome | 541 | |
| chr9:38,689,638–38,690,086 | 265.4 kb | Distal (>10kb) Multiome | 159 |
Genomic view of the IGFBPL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.