IFT172

intraflagellar transport 172 | BBS20, NPHP17, SLB, osm-1, wim

This gene encodes a subunit of the intraflagellar transport subcomplex IFT-B. Subcomplexes IFT-A and IFT-B are necessary for ciliary assembly and maintenance. Mutations in this gene have been associated with skeletal ciliopathies, with or without polydactyly, such as such short-rib thoracic dysplasias 1, 9 or 10. [provided by RefSeq, Mar 2014]

Member of: DE-5

Biological processes 25 terms

axoneme (GO:0005930)ciliary basal body (GO:0036064)ciliary tip (GO:0097542)cilium (GO:0005929)cilium (GO:0005929)cilium (GO:0005929)cilium (GO:0005929)cilium assembly (GO:0060271)cilium assembly (GO:0060271)cilium assembly (GO:0060271)cilium assembly (GO:0060271)cilium organization (GO:0044782)extracellular vesicle (GO:1903561)intraciliary anterograde transport (GO:0035720)intraciliary transport (GO:0042073)intraciliary transport particle (GO:0030990)intraciliary transport particle A (GO:0030991)intraciliary transport particle B (GO:0030992)intraciliary transport particle B (GO:0030992)intraciliary transport particle B (GO:0030992)protein binding (GO:0005515)smoothened signaling pathway (GO:0007224)sperm cytoplasmic droplet (GO:0097598)sperm midpiece (GO:0097225)sperm principal piece (GO:0097228)

Expression (TPM)

TFs regulating IFT172 0 TFs

Transcription factors with Perturb-seq knockdown data for IFT172. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IFT172 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to IFT172

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IFT172, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr2:27,211,255–27,212,840	277.6 kb	Distal (>10kb) Multiome	978
chr2:27,217,045–27,218,005	272.4 kb	Distal (>10kb) Multiome	771
chr2:27,250,040–27,250,883	239.4 kb	Distal (>10kb) Multiome	559
chr2:27,262,260–27,263,337	226.8 kb	Distal (>10kb) Multiome	376
chr2:27,264,406–27,265,326	224.6 kb	Distal (>10kb) Multiome	696
chr2:27,306,488–27,307,261	183.1 kb	Distal (>10kb) Multiome	115
chr2:27,322,773–27,323,423	166.7 kb	Distal (>10kb) Multiome	906
chr2:27,356,094–27,357,596	132.8 kb	Distal (>10kb) Multiome	1084
chr2:27,369,685–27,371,261	119.4 kb	Distal (>10kb) Multiome	1096
chr2:27,380,026–27,381,202	109.0 kb	Distal (>10kb) Multiome	821
chr2:27,408,972–27,410,056	80.1 kb	Distal (>10kb) Multiome	989
chr2:27,428,202–27,429,633	61.1 kb	Distal (>10kb) Multiome	1013
chr2:27,441,811–27,442,884	47.4 kb	Distal (>10kb) Multiome	380
chr2:27,489,334–27,490,205	65 bp	At TSS Multiome	731
chr2:27,494,797–27,495,577	5.4 kb	Proximal (<10kb) Multiome	380
chr2:27,517,085–27,517,958	27.8 kb	Distal (>10kb) Multiome	130
chr2:27,582,572–27,583,317	93.2 kb	Distal (>10kb) Multiome	843
chr2:27,628,534–27,629,380	139.2 kb	Distal (>10kb) Multiome	828
chr2:27,663,338–27,664,216	174.0 kb	Distal (>10kb) Multiome	1035
chr2:27,681,105–27,682,049	191.9 kb	Distal (>10kb) Multiome	85
chr2:27,715,293–27,715,981	226.2 kb	Distal (>10kb) Multiome	346
chr2:27,735,279–27,736,049	245.8 kb	Distal (>10kb) Multiome	395
chr2:27,752,465–27,753,359	263.1 kb	Distal (>10kb) Multiome	577
chr2:27,771,346–27,772,271	282.0 kb	Distal (>10kb) Multiome	941

Genome Browser

Genomic view of the IFT172 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.