The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ID1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ID1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ID1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:31,514,040–31,515,233 | 90.8 kb | Distal (>10kb) Multiome | 1014 | |
| chr20:31,572,435–31,573,822 | 32.1 kb | Distal (>10kb) Multiome | 1193 | |
| chr20:31,595,608–31,596,479 | 9.3 kb | Proximal (<10kb) Multiome | 676 | |
| chr20:31,604,042–31,606,325 | 1.1 kb | Proximal (<10kb) Multiome | 1198 | |
| chr20:31,606,499–31,608,983 | 3.4 kb | Proximal (<10kb) Multiome | 1081 | |
| chr20:31,611,589–31,611,802 | 6.3 kb | Proximal (<10kb) | 101 | |
| chr20:31,612,623–31,613,367 | 7.7 kb | Proximal (<10kb) Multiome | 858 | |
| chr20:31,661,610–31,662,406 | 56.5 kb | Distal (>10kb) Multiome | 836 | |
| chr20:31,693,987–31,694,929 | 89.1 kb | Distal (>10kb) Multiome | 357 | |
| chr20:31,722,556–31,724,276 | 118.4 kb | Distal (>10kb) Multiome | 1147 | |
| chr20:31,738,777–31,739,576 | 133.9 kb | Distal (>10kb) Multiome | 923 | |
| chr20:31,822,496–31,823,111 | 217.7 kb | Distal (>10kb) Multiome | 479 | |
| chr20:31,860,463–31,862,362 | 256.5 kb | Distal (>10kb) Multiome | 627 | |
| chr20:31,870,005–31,870,863 | 265.1 kb | Distal (>10kb) Multiome | 460 | |
| chr20:31,879,388–31,880,438 | 274.6 kb | Distal (>10kb) Multiome | 900 |
Genomic view of the ID1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.