Enables protein-macromolecule adaptor activity. Involved in several processes, including positive regulation of intracellular protein transport; positive regulation of transcription by RNA polymerase III; and snRNA transcription. Located in Cajal body; euchromatin; and histone locus body. Part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ICE1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ICE1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ICE1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:5,139,356–5,140,841 | 282.6 kb | Distal (>10kb) Multiome HiCAR | 364 | |
| chr5:5,179,195–5,180,337 | 242.9 kb | Distal (>10kb) Multiome HiCAR | 139 | |
| chr5:5,182,894–5,183,828 | 239.2 kb | Distal (>10kb) Multiome | 303 | |
| chr5:5,198,807–5,199,844 | 223.5 kb | Distal (>10kb) Multiome | 128 | |
| chr5:5,270,819–5,272,461 | 151.2 kb | Distal (>10kb) Multiome | 448 | |
| chr5:5,419,263–5,419,639 | 3.0 kb | Proximal (<10kb) | 120 | |
| chr5:5,421,006–5,423,420 | 251 bp | At TSS Multiome | 913 | |
| chr5:5,429,028–5,429,534 | 6.4 kb | Proximal (<10kb) | 15 | |
| chr5:5,494,413–5,495,371 | 72.1 kb | Distal (>10kb) Multiome | 282 | |
| chr5:5,558,130–5,559,597 | 136.1 kb | Distal (>10kb) Multiome | 144 | |
| chr5:5,559,744–5,560,419 | 137.5 kb | Distal (>10kb) Multiome | 157 |
Genomic view of the ICE1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.