Transcription factors with Perturb-seq knockdown data for HSDL2-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HSDL2-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HSDL2-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:112,332,780–112,334,661 | 152.9 kb | Distal (>10kb) Multiome | 913 | |
| chr9:112,379,308–112,380,565 | 106.7 kb | Distal (>10kb) Multiome | 895 | |
| chr9:112,486,079–112,487,780 | 94 bp | At TSS Multiome | 1004 | |
| chr9:112,489,029–112,489,414 | 2.3 kb | Proximal (<10kb) | 172 | |
| chr9:112,717,577–112,718,753 | 231.5 kb | Distal (>10kb) Multiome | 751 | |
| chr9:112,750,159–112,751,980 | 264.0 kb | Distal (>10kb) Multiome | 907 | |
| chr9:112,771,981–112,772,634 | 285.6 kb | Distal (>10kb) Multiome | 89 |
Genomic view of the HSDL2-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.