Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009]
Transcription factors with Perturb-seq knockdown data for HSD17B11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HSD17B11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HSD17B11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:87,219,648–87,221,398 | 170.6 kb | Distal (>10kb) Multiome | 820 | |
| chr4:87,390,942–87,391,806 | 151 bp | At TSS Multiome | 801 | |
| chr4:87,399,248–87,399,440 | 8.1 kb | Proximal (<10kb) | 31 | |
| chr4:87,422,060–87,423,097 | 31.5 kb | Distal (>10kb) Multiome | 963 | |
| chr4:87,520,153–87,520,890 | 129.4 kb | Distal (>10kb) Multiome | 177 |
Genomic view of the HSD17B11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.