This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus early-1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by early-1B-55kDa in adenovirus-infected cells. [provided by RefSeq, Mar 2016]
Transcription factors with Perturb-seq knockdown data for HNRNPUL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HNRNPUL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HNRNPUL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:41,175,862–41,176,466 | 88.2 kb | Distal (>10kb) Multiome | 330 | |
| chr19:41,192,831–41,193,504 | 71.2 kb | Distal (>10kb) Multiome | 377 | |
| chr19:41,218,771–41,219,447 | 45.4 kb | Distal (>10kb) Multiome | 345 | |
| chr19:41,262,152–41,262,839 | 2.0 kb | Proximal (<10kb) Multiome | 787 | |
| chr19:41,262,983–41,265,249 | 333 bp | At TSS Multiome | 1022 | |
| chr19:41,309,685–41,310,764 | 45.8 kb | Distal (>10kb) Multiome | 1016 | |
| chr19:41,324,382–41,326,571 | 60.8 kb | Distal (>10kb) Multiome | 670 | |
| chr19:41,351,173–41,351,794 | 87.1 kb | Distal (>10kb) Multiome | 465 | |
| chr19:41,352,533–41,354,401 | 89.6 kb | Distal (>10kb) Multiome | 807 | |
| chr19:41,363,475–41,364,733 | 99.7 kb | Distal (>10kb) Multiome | 774 | |
| chr19:41,376,421–41,376,995 | 112.3 kb | Distal (>10kb) Multiome | 379 | |
| chr19:41,397,079–41,398,056 | 133.1 kb | Distal (>10kb) Multiome | 849 | |
| chr19:41,406,970–41,407,622 | 142.9 kb | Distal (>10kb) Multiome | 88 | |
| chr19:41,426,905–41,428,213 | 163.1 kb | Distal (>10kb) Multiome | 512 | |
| chr19:41,439,463–41,440,163 | 175.4 kb | Distal (>10kb) Multiome | 765 | |
| chr19:41,548,798–41,549,566 | 284.8 kb | Distal (>10kb) Multiome | 212 | |
| chr19:41,563,228–41,563,884 | 299.1 kb | Distal (>10kb) Multiome | 419 |
Genomic view of the HNRNPUL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.