This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is localized in nuclear bodies of the nucleus. This protein is involved in the splicing process and it also participates in early heat shock-induced splicing arrest by transiently leaving the hnRNP complexes. Several alternatively spliced transcript variants have been noted for this gene, however, not all are fully characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for HNRNPH3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HNRNPH3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HNRNPH3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:68,074,303–68,075,534 | 256.9 kb | Distal (>10kb) Multiome | 860 | |
| chr10:68,208,472–68,208,961 | 123.4 kb | Distal (>10kb) Multiome | 254 | |
| chr10:68,231,028–68,232,253 | 100.5 kb | Distal (>10kb) Multiome HiCAR | 654 | |
| chr10:68,271,165–68,272,025 | 60.5 kb | Distal (>10kb) Multiome | 177 | |
| chr10:68,331,343–68,333,064 | 940 bp | At TSS Multiome | 1174 | |
| chr10:68,406,245–68,407,662 | 75.2 kb | Distal (>10kb) Multiome | 898 | |
| chr10:68,471,473–68,472,528 | 139.9 kb | Distal (>10kb) Multiome | 831 | |
| chr10:68,527,011–68,528,012 | 195.5 kb | Distal (>10kb) Multiome | 912 | |
| chr10:68,559,963–68,561,065 | 228.3 kb | Distal (>10kb) Multiome | 777 | |
| chr10:68,600,036–68,600,760 | 268.4 kb | Distal (>10kb) Multiome | 755 |
Genomic view of the HNRNPH3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.