Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nucleus. Predicted to be part of catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HNRNPA1L3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HNRNPA1L3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HNRNPA1L3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:51,151,063–51,154,044 | 493.3 kb | Distal (>10kb) Multiome HiCAR | 698 | |
| chr16:51,391,732–51,393,055 | 253.6 kb | Distal (>10kb) Multiome | 190 | |
| chr16:51,449,102–51,449,934 | 196.2 kb | Distal (>10kb) Multiome | 110 | |
| chr16:51,526,672–51,527,309 | 118.9 kb | Distal (>10kb) Multiome | 68 | |
| chr16:51,544,684–51,545,392 | 8.0 kb | Proximal (<10kb) | 122 | |
| chr16:51,545,603–51,546,571 | 99.5 kb | Distal (>10kb) Multiome | 67 | |
| chr16:51,636,923–51,637,319 | 8.4 kb | Proximal (<10kb) | 118 | |
| chr16:51,849,376–51,850,215 | 204.2 kb | Distal (>10kb) Multiome | 195 |
Genomic view of the HNRNPA1L3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.