Enables protein homodimerization activity. Predicted to be involved in acetyl-CoA metabolic process and farnesyl diphosphate biosynthetic process, mevalonate pathway. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HMGCS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HMGCS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HMGCS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:43,016,201–43,016,848 | 297.0 kb | Distal (>10kb) Multiome | 194 | |
| chr5:43,017,299–43,018,875 | 295.4 kb | Distal (>10kb) Multiome | 870 | |
| chr5:43,024,983–43,026,034 | 287.9 kb | Distal (>10kb) Multiome | 130 | |
| chr5:43,041,652–43,043,529 | 271.2 kb | Distal (>10kb) Multiome | 897 | |
| chr5:43,064,252–43,065,217 | 248.4 kb | Distal (>10kb) Multiome | 959 | |
| chr5:43,065,881–43,067,664 | 246.8 kb | Distal (>10kb) Multiome | 928 | |
| chr5:43,105,415–43,106,204 | 207.6 kb | Distal (>10kb) Multiome | 820 | |
| chr5:43,120,453–43,122,435 | 192.0 kb | Distal (>10kb) Multiome | 1097 | |
| chr5:43,191,656–43,192,908 | 121.3 kb | Distal (>10kb) Multiome | 475 | |
| chr5:43,306,059–43,306,453 | 7.0 kb | Proximal (<10kb) | 136 | |
| chr5:43,309,268–43,309,642 | 3.8 kb | Proximal (<10kb) | 32 | |
| chr5:43,312,549–43,314,340 | 201 bp | At TSS Multiome | 954 | |
| chr5:43,348,196–43,348,656 | 35.0 kb | Distal (>10kb) Multiome | 141 | |
| chr5:43,396,804–43,397,322 | 83.7 kb | Distal (>10kb) Multiome | 340 | |
| chr5:43,416,225–43,416,784 | 103.0 kb | Distal (>10kb) Multiome | 263 | |
| chr5:43,483,333–43,484,741 | 170.5 kb | Distal (>10kb) Multiome | 1033 | |
| chr5:43,514,568–43,515,502 | 201.7 kb | Distal (>10kb) Multiome | 817 | |
| chr5:43,555,878–43,557,718 | 243.5 kb | Distal (>10kb) Multiome | 936 | |
| chr5:43,602,369–43,604,281 | 289.7 kb | Distal (>10kb) Multiome | 912 |
Genomic view of the HMGCS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.