Predicted to enable ubiquitin-protein transferase activity. Involved in glucose homeostasis and glucose metabolic process. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HECTD4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HECTD4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HECTD4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:112,108,135–112,109,541 | 273.6 kb | Distal (>10kb) Multiome | 788 | |
| chr12:112,116,420–112,116,883 | 265.7 kb | Distal (>10kb) Multiome | 549 | |
| chr12:112,125,273–112,125,989 | 256.9 kb | Distal (>10kb) Multiome | 798 | |
| chr12:112,381,577–112,382,895 | 6 bp | At TSS Multiome | 774 | |
| chr12:112,387,444–112,387,871 | 5.0 kb | Proximal (<10kb) | 350 | |
| chr12:112,409,112–112,409,791 | 27.1 kb | Distal (>10kb) Multiome | 866 | |
| chr12:112,418,542–112,419,596 | 36.6 kb | Distal (>10kb) Multiome | 960 | |
| chr12:112,577,793–112,578,332 | 195.7 kb | Distal (>10kb) Multiome | 187 |
Genomic view of the HECTD4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.