The protein encoded by this gene transfers ubiquitin from an E2 ubiquitin-conjugating enzyme to targeted substrates, leading to the degradation of those substrates. The encoded protein has been shown to transfer ubiquitin to TRIOBP to facilitate cell cycle progression, and to STX8. [provided by RefSeq, Dec 2012]
Transcription factors with Perturb-seq knockdown data for HECTD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HECTD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HECTD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:44,720,791–44,722,329 | 289.6 kb | Distal (>10kb) Multiome | 1059 | |
| chr1:44,730,465–44,731,848 | 280.3 kb | Distal (>10kb) Multiome | 1164 | |
| chr1:44,739,368–44,740,265 | 271.6 kb | Distal (>10kb) Multiome | 828 | |
| chr1:44,775,008–44,776,007 | 235.8 kb | Distal (>10kb) Multiome | 1041 | |
| chr1:44,783,907–44,784,940 | 226.9 kb | Distal (>10kb) Multiome HiCAR | 497 | |
| chr1:44,786,163–44,786,815 | 224.9 kb | Distal (>10kb) Multiome HiCAR | 616 | |
| chr1:44,799,477–44,801,039 | 211.2 kb | Distal (>10kb) Multiome HiCAR | 1017 | |
| chr1:44,807,115–44,808,920 | 202.7 kb | Distal (>10kb) Multiome HiCAR | 987 | |
| chr1:44,812,965–44,814,105 | 197.5 kb | Distal (>10kb) Multiome | 349 | |
| chr1:44,818,937–44,820,693 | 191.4 kb | Distal (>10kb) Multiome HiCAR | 1101 | |
| chr1:44,842,822–44,843,695 | 168.0 kb | Distal (>10kb) Multiome HiCAR | 539 | |
| chr1:44,986,311–44,986,894 | 24.7 kb | Distal (>10kb) Multiome | 979 | |
| chr1:45,010,856–45,013,180 | 901 bp | At TSS Multiome | 909 | |
| chr1:45,014,536–45,014,759 | 3.2 kb | Proximal (<10kb) | 267 | |
| chr1:45,018,707–45,018,961 | 7.4 kb | Proximal (<10kb) | 178 | |
| chr1:45,205,664–45,207,097 | 195.2 kb | Distal (>10kb) Multiome | 691 | |
| chr1:45,216,712–45,217,234 | 205.7 kb | Distal (>10kb) Multiome HiCAR | 42 | |
| chr1:45,303,203–45,304,881 | 292.5 kb | Distal (>10kb) Multiome HiCAR | 1034 | |
| chr1:45,315,837–45,316,870 | 304.8 kb | Distal (>10kb) Multiome HiCAR | 113 | |
| chr1:45,317,165–45,317,643 | 306.1 kb | Distal (>10kb) Multiome HiCAR | 7 | |
| chr1:45,321,623–45,322,180 | 310.4 kb | Distal (>10kb) Multiome HiCAR | 54 | |
| chr1:45,326,327–45,328,092 | 315.5 kb | Distal (>10kb) Multiome HiCAR | 382 | |
| chr1:45,339,505–45,340,694 | 328.8 kb | Distal (>10kb) Multiome HiCAR | 951 | |
| chr1:45,490,605–45,491,773 | 480.0 kb | Distal (>10kb) Multiome HiCAR | 900 | |
| chr1:45,499,499–45,500,620 | 488.8 kb | Distal (>10kb) Multiome HiCAR | 831 |
Genomic view of the HECTD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.