Predicted to be involved in endocytosis; protein localization; and retrograde transport, endosome to Golgi. Located in Golgi apparatus; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HEATR5B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HEATR5B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HEATR5B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:36,965,735–36,967,324 | 117.7 kb | Distal (>10kb) Multiome | 1026 | |
| chr2:37,083,780–37,086,187 | 1.4 kb | Proximal (<10kb) Multiome | 938 | |
| chr2:37,156,055–37,157,536 | 72.6 kb | Distal (>10kb) Multiome | 702 | |
| chr2:37,205,153–37,205,870 | 121.0 kb | Distal (>10kb) Multiome | 157 | |
| chr2:37,231,272–37,232,043 | 147.2 kb | Distal (>10kb) Multiome | 891 | |
| chr2:37,305,706–37,306,783 | 221.7 kb | Distal (>10kb) Multiome | 129 | |
| chr2:37,323,791–37,325,583 | 240.5 kb | Distal (>10kb) Multiome | 835 |
Genomic view of the HEATR5B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.