The protein encoded by this gene plays a role in ribosomal protein transport and in the assembly of the 5S ribonucleoprotein particle (5S RNP). The encoded protein also may be involved in NOD2-mediated NF-kappaB signaling. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for HEATR3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HEATR3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HEATR3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:49,838,622–49,839,188 | 227.1 kb | Distal (>10kb) Multiome | 82 | |
| chr16:49,854,387–49,856,396 | 210.3 kb | Distal (>10kb) Multiome | 495 | |
| chr16:49,856,552–49,859,437 | 208.8 kb | Distal (>10kb) Multiome | 535 | |
| chr16:49,876,274–49,877,137 | 189.2 kb | Distal (>10kb) Multiome | 296 | |
| chr16:50,024,713–50,025,833 | 40.8 kb | Distal (>10kb) Multiome | 882 | |
| chr16:50,065,596–50,066,866 | 150 bp | At TSS Multiome | 839 | |
| chr16:50,152,387–50,154,528 | 87.1 kb | Distal (>10kb) Multiome | 930 |
Genomic view of the HEATR3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.