The protein encoded by this gene binds high density lipoprotein (HDL) and may function to regulate excess cholesterol levels in cells. The encoded protein also binds RNA and can induce heterochromatin formation. [provided by RefSeq, Mar 2016]
Transcription factors with Perturb-seq knockdown data for HDLBP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HDLBP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HDLBP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:241,102,057–241,102,727 | 213.3 kb | Distal (>10kb) Multiome | 1072 | |
| chr2:241,148,805–241,150,972 | 166.3 kb | Distal (>10kb) Multiome | 897 | |
| chr2:241,217,134–241,217,954 | 98.0 kb | Distal (>10kb) Multiome | 700 | |
| chr2:241,272,147–241,273,188 | 42.9 kb | Distal (>10kb) Multiome | 539 | |
| chr2:241,314,756–241,316,790 | 200 bp | At TSS Multiome | 1143 | |
| chr2:241,354,545–241,355,644 | 39.3 kb | Distal (>10kb) Multiome | 625 | |
| chr2:241,355,946–241,356,875 | 40.5 kb | Distal (>10kb) Multiome | 680 | |
| chr2:241,507,257–241,509,444 | 193.0 kb | Distal (>10kb) Multiome | 1050 | |
| chr2:241,540,846–241,542,485 | 225.6 kb | Distal (>10kb) Multiome | 394 | |
| chr2:241,558,542–241,559,899 | 243.1 kb | Distal (>10kb) Multiome | 638 | |
| chr2:241,609,833–241,610,860 | 294.7 kb | Distal (>10kb) Multiome | 755 |
Genomic view of the HDLBP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.