Predicted to enable microtubule binding activity. Predicted to be involved in microtubule polymerization; negative regulation of microtubule depolymerization; and neuron projection development. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HDGFL3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HDGFL3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HDGFL3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:82,910,611–82,911,202 | 296.9 kb | Distal (>10kb) Multiome | 35 | |
| chr15:82,952,161–82,953,316 | 255.1 kb | Distal (>10kb) Multiome | 430 | |
| chr15:82,985,830–82,986,497 | 221.7 kb | Distal (>10kb) Multiome | 853 | |
| chr15:83,010,925–83,012,341 | 196.2 kb | Distal (>10kb) Multiome | 964 | |
| chr15:83,066,587–83,067,782 | 140.6 kb | Distal (>10kb) Multiome | 877 | |
| chr15:83,106,916–83,108,096 | 100.5 kb | Distal (>10kb) Multiome | 392 | |
| chr15:83,143,995–83,145,038 | 63.6 kb | Distal (>10kb) Multiome | 146 | |
| chr15:83,178,820–83,179,295 | 28.9 kb | Distal (>10kb) Multiome | 114 | |
| chr15:83,206,651–83,208,545 | 328 bp | At TSS Multiome | 607 | |
| chr15:83,378,916–83,379,702 | 171.4 kb | Distal (>10kb) Multiome | 191 | |
| chr15:83,446,671–83,448,301 | 239.5 kb | Distal (>10kb) Multiome | 542 |
Genomic view of the HDGFL3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.