Predicted to enable 5'-deoxynucleotidase activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HDDC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HDDC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HDDC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:125,099,255–125,100,053 | 202.3 kb | Distal (>10kb) Multiome | 540 | |
| chr6:125,153,568–125,155,310 | 147.0 kb | Distal (>10kb) Multiome | 927 | |
| chr6:125,301,431–125,302,347 | 101 bp | At TSS Multiome | 1009 | |
| chr6:125,311,097–125,311,372 | 9.1 kb | Proximal (<10kb) | 149 | |
| chr6:125,363,077–125,364,300 | 61.8 kb | Distal (>10kb) Multiome | 554 | |
| chr6:125,421,627–125,422,704 | 120.1 kb | Distal (>10kb) Multiome | 252 | |
| chr6:125,528,427–125,529,436 | 226.9 kb | Distal (>10kb) Multiome | 266 | |
| chr6:125,747,542–125,750,482 | 447.6 kb | Distal (>10kb) Multiome HiCAR | 891 | |
| chr6:125,780,157–125,781,423 | 478.4 kb | Distal (>10kb) Multiome HiCAR | 1022 | |
| chr6:125,789,677–125,791,851 | 488.8 kb | Distal (>10kb) Multiome HiCAR | 1017 | |
| chr6:125,867,468–125,867,998 | 565.8 kb | Distal (>10kb) Multiome HiCAR | 264 | |
| chr6:125,952,889–125,953,903 | 651.6 kb | Distal (>10kb) Multiome HiCAR | 343 | |
| chr6:125,956,540–125,957,527 | 654.9 kb | Distal (>10kb) Multiome HiCAR | 1085 | |
| chr6:125,986,066–125,987,257 | 684.5 kb | Distal (>10kb) Multiome HiCAR | 925 |
Genomic view of the HDDC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.