Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for HDAC7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HDAC7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HDAC7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:47,636,966–47,637,678 | 182.6 kb | Distal (>10kb) Multiome | 111 | |
| chr12:47,705,453–47,706,210 | 113.9 kb | Distal (>10kb) Multiome | 859 | |
| chr12:47,717,388–47,718,196 | 102.1 kb | Distal (>10kb) Multiome | 330 | |
| chr12:47,757,825–47,759,674 | 60.7 kb | Distal (>10kb) Multiome | 644 | |
| chr12:47,772,964–47,774,017 | 46.6 kb | Distal (>10kb) Multiome | 568 | |
| chr12:47,778,984–47,779,897 | 40.4 kb | Distal (>10kb) Multiome | 320 | |
| chr12:47,810,986–47,811,164 | 8.7 kb | Proximal (<10kb) | 48 | |
| chr12:47,812,831–47,813,817 | 6.8 kb | Proximal (<10kb) Multiome | 555 | |
| chr12:47,818,868–47,821,142 | 84 bp | At TSS Multiome HiCAR | 777 | |
| chr12:47,828,997–47,829,219 | 9.1 kb | Proximal (<10kb) | 347 | |
| chr12:47,904,573–47,905,755 | 85.3 kb | Distal (>10kb) Multiome | 575 | |
| chr12:47,942,159–47,942,641 | 122.6 kb | Distal (>10kb) Multiome | 160 | |
| chr12:47,963,134–47,964,083 | 143.7 kb | Distal (>10kb) Multiome | 742 | |
| chr12:48,000,982–48,002,307 | 181.7 kb | Distal (>10kb) Multiome | 379 | |
| chr12:48,003,968–48,005,434 | 184.8 kb | Distal (>10kb) Multiome | 366 | |
| chr12:48,021,709–48,022,295 | 202.0 kb | Distal (>10kb) Multiome | 419 | |
| chr12:48,023,364–48,024,084 | 203.7 kb | Distal (>10kb) Multiome | 188 | |
| chr12:48,037,309–48,037,998 | 217.7 kb | Distal (>10kb) Multiome | 157 | |
| chr12:48,105,562–48,106,521 | 286.2 kb | Distal (>10kb) Multiome | 962 | |
| chr12:48,118,916–48,119,822 | 299.5 kb | Distal (>10kb) Multiome | 486 |
Genomic view of the HDAC7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.