Enables several functions, including 2-hydroxyacyl-CoA lyase activity; ATP binding activity; and cation binding activity. Involved in fatty acid alpha-oxidation; phytanic acid metabolic process; and protein targeting to peroxisome. Located in nucleoplasm and peroxisome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HACL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HACL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HACL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:15,305,253–15,306,068 | 295.9 kb | Distal (>10kb) Multiome | 367 | |
| chr3:15,331,772–15,333,155 | 268.9 kb | Distal (>10kb) Multiome | 642 | |
| chr3:15,356,271–15,357,033 | 244.9 kb | Distal (>10kb) Multiome | 98 | |
| chr3:15,377,980–15,378,549 | 223.2 kb | Distal (>10kb) Multiome | 575 | |
| chr3:15,427,190–15,427,854 | 174.1 kb | Distal (>10kb) Multiome | 758 | |
| chr3:15,858,901–15,861,637 | 258.3 kb | Distal (>10kb) Multiome | 981 |
Genomic view of the HACL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.