HABP4

hyaluronan binding protein 4 | IHABP4, SERBP1L

Enables SUMO binding activity. Involved in PML body organization; positive regulation of RNA splicing; and positive regulation of translational initiation. Located in several cellular components, including cytoplasmic stress granule; nuclear lumen; and nuclear membrane. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-5 DE-5.7

Biological processes 40 terms

Cajal body (GO:0015030)Cajal body (GO:0015030)Gemini of Cajal bodies (GO:0097504)Gemini of Cajal bodies (GO:0097504)PML body organization (GO:0030578)RNA binding (GO:0003723)RNA binding (GO:0003723)SUMO binding (GO:0032183)cellular response to mechanical stimulus (GO:0071260)cellular response to mechanical stimulus (GO:0071260)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasmic stress granule (GO:0010494)cytoplasmic stress granule (GO:0010494)cytosol (GO:0005829)cytosol (GO:0005829)extracellular region (GO:0005576)nuclear body (GO:0016604)nuclear membrane (GO:0031965)nuclear speck (GO:0016607)nuclear speck (GO:0016607)nucleolus (GO:0005730)nucleolus (GO:0005730)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of RNA splicing (GO:0033120)positive regulation of RNA splicing (GO:0033120)positive regulation of translational initiation (GO:0045948)positive regulation of translational initiation (GO:0045948)protein binding (GO:0005515)ribosome binding (GO:0043022)ribosome hibernation (GO:0141014)sarcomere (GO:0030017)sarcomere (GO:0030017)sarcoplasm (GO:0016528)translation elongation factor binding (GO:0061770)

Expression (TPM)

TFs regulating HABP4 0 TFs

Transcription factors with Perturb-seq knockdown data for HABP4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HABP4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to HABP4

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HABP4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr9:96,217,334–96,218,659	231.9 kb	Distal (>10kb) Multiome	570
chr9:96,383,184–96,383,893	66.6 kb	Distal (>10kb) Multiome	519
chr9:96,416,915–96,419,539	32.9 kb	Distal (>10kb) Multiome	1128
chr9:96,449,559–96,451,233	101 bp	At TSS Multiome	666
chr9:96,543,037–96,543,508	93.1 kb	Distal (>10kb) Multiome	76
chr9:96,566,442–96,567,471	116.8 kb	Distal (>10kb) Multiome	819
chr9:96,618,860–96,620,237	169.6 kb	Distal (>10kb) Multiome	570
chr9:96,620,809–96,621,291	170.9 kb	Distal (>10kb) Multiome	143
chr9:96,654,449–96,655,707	205.1 kb	Distal (>10kb) Multiome	706
chr9:96,686,688–96,687,337	236.8 kb	Distal (>10kb) Multiome	253

Genome Browser

Genomic view of the HABP4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.