Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. Several transcript variants encoding different isoforms, have been identified for this gene. [provided by RefSeq, Oct 2015]
Transcription factors with Perturb-seq knockdown data for H2AZ2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = H2AZ2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of H2AZ2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:44,573,627–44,574,398 | 274.0 kb | Distal (>10kb) Multiome | 885 | |
| chr7:44,581,475–44,583,147 | 265.7 kb | Distal (>10kb) Multiome | 864 | |
| chr7:44,606,125–44,607,487 | 241.2 kb | Distal (>10kb) Multiome | 1043 | |
| chr7:44,748,085–44,749,703 | 99.4 kb | Distal (>10kb) Multiome | 665 | |
| chr7:44,795,796–44,797,747 | 51.5 kb | Distal (>10kb) Multiome | 1094 | |
| chr7:44,847,376–44,848,800 | 137 bp | At TSS Multiome | 990 | |
| chr7:44,856,973–44,857,319 | 8.9 kb | Proximal (<10kb) | 434 | |
| chr7:44,884,668–44,886,169 | 37.5 kb | Distal (>10kb) Multiome | 956 | |
| chr7:44,962,460–44,963,298 | 114.9 kb | Distal (>10kb) Multiome | 179 | |
| chr7:44,986,037–44,987,077 | 138.7 kb | Distal (>10kb) Multiome | 748 | |
| chr7:44,999,127–45,000,858 | 151.9 kb | Distal (>10kb) Multiome | 706 | |
| chr7:45,051,984–45,052,624 | 204.3 kb | Distal (>10kb) Multiome | 90 | |
| chr7:45,088,228–45,089,744 | 241.2 kb | Distal (>10kb) Multiome | 375 | |
| chr7:45,111,371–45,112,159 | 263.7 kb | Distal (>10kb) Multiome | 1026 |
Genomic view of the H2AZ2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.