H1-5

H1.5 linker histone, cluster member | H1b, H1s-3, H1F5, HIST1H1B

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

Member of: DE-6 DE-6.13

Biological processes 26 terms

DNA binding (GO:0003677)RNA binding (GO:0003723)chromatin (GO:0000785)chromatin (GO:0000785)chromatin DNA binding (GO:0031490)chromatin DNA binding (GO:0031490)chromatin organization (GO:0006325)chromosome (GO:0005694)chromosome condensation (GO:0030261)double-stranded DNA binding (GO:0003690)establishment of protein localization to chromatin (GO:0071169)euchromatin (GO:0000791)heterochromatin (GO:0000792)histone deacetylase binding (GO:0042826)negative regulation of DNA recombination (GO:0045910)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleoplasm (GO:0005654)nucleosomal DNA binding (GO:0031492)nucleosome (GO:0000786)nucleosome assembly (GO:0006334)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)protein stabilization (GO:0050821)structural constituent of chromatin (GO:0030527)

Expression (TPM)

TFs regulating H1-5 0 TFs

Transcription factors with Perturb-seq knockdown data for H1-5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = H1-5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to H1-5

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of H1-5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr6:26,031,341–26,032,990	1835.4 kb	Distal (>10kb) Multiome HiCAR	1083
chr6:26,033,113–26,034,309	1833.9 kb	Distal (>10kb) Multiome HiCAR	800
chr6:26,054,926–26,057,287	1812.2 kb	Distal (>10kb) Multiome HiCAR	1174
chr6:26,122,481–26,124,909	1744.6 kb	Distal (>10kb) Multiome HiCAR	1216
chr6:26,125,788–26,126,592	1741.4 kb	Distal (>10kb) Multiome HiCAR	670
chr6:26,156,184–26,158,744	1709.5 kb	Distal (>10kb) Multiome HiCAR	1310
chr6:26,171,798–26,172,499	1695.6 kb	Distal (>10kb) Multiome HiCAR	580
chr6:26,183,128–26,184,377	1683.8 kb	Distal (>10kb) Multiome HiCAR	311
chr6:26,187,874–26,189,538	1678.5 kb	Distal (>10kb) Multiome HiCAR	1053
chr6:26,196,695–26,197,676	1670.3 kb	Distal (>10kb) Multiome HiCAR	842
chr6:26,198,203–26,200,197	1668.2 kb	Distal (>10kb) Multiome HiCAR	939
chr6:26,203,791–26,205,119	1663.1 kb	Distal (>10kb) Multiome HiCAR	1071
chr6:26,214,872–26,218,468	1650.7 kb	Distal (>10kb) Multiome HiCAR	1096
chr6:26,223,716–26,224,480	1643.6 kb	Distal (>10kb) Multiome HiCAR	507
chr6:26,224,856–26,226,566	1642.4 kb	Distal (>10kb) Multiome HiCAR	451
chr6:26,239,944–26,240,920	1627.2 kb	Distal (>10kb) Multiome HiCAR	375
chr6:26,249,682–26,251,138	1617.3 kb	Distal (>10kb) Multiome HiCAR	731
chr6:26,251,339–26,252,079	1615.8 kb	Distal (>10kb) Multiome HiCAR	445
chr6:26,270,815–26,273,967	1594.7 kb	Distal (>10kb) Multiome HiCAR	742
chr6:26,285,011–26,286,121	1582.0 kb	Distal (>10kb) Multiome HiCAR	1121
chr6:27,145,480–27,148,111	720.5 kb	Distal (>10kb) Multiome HiCAR	951
chr6:27,592,359–27,593,376	274.7 kb	Distal (>10kb) Multiome	844
chr6:27,602,046–27,602,794	265.1 kb	Distal (>10kb) Multiome	469
chr6:27,605,356–27,606,138	261.8 kb	Distal (>10kb) Multiome	562
chr6:27,630,675–27,631,795	236.4 kb	Distal (>10kb) Multiome	827
chr6:27,650,587–27,651,063	216.7 kb	Distal (>10kb) Multiome	541
chr6:27,668,541–27,669,069	198.9 kb	Distal (>10kb) Multiome	577
chr6:27,671,980–27,673,036	195.2 kb	Distal (>10kb) Multiome	845
chr6:27,684,282–27,684,819	183.0 kb	Distal (>10kb) Multiome	652
chr6:27,687,268–27,688,540	179.9 kb	Distal (>10kb) Multiome	972
chr6:27,752,061–27,752,956	115.2 kb	Distal (>10kb) Multiome	499
chr6:27,753,073–27,753,588	114.2 kb	Distal (>10kb) Multiome	758
chr6:27,762,370–27,762,921	104.9 kb	Distal (>10kb) Multiome	65
chr6:27,772,302–27,773,105	94.9 kb	Distal (>10kb) Multiome	784
chr6:27,791,232–27,791,741	76.2 kb	Distal (>10kb) Multiome	564
chr6:27,791,916–27,792,609	75.2 kb	Distal (>10kb) Multiome	728
chr6:27,806,645–27,808,975	59.6 kb	Distal (>10kb) Multiome	963
chr6:27,809,816–27,810,576	57.5 kb	Distal (>10kb) Multiome	914
chr6:27,813,688–27,816,146	52.6 kb	Distal (>10kb) Multiome	564
chr6:27,836,792–27,839,128	29.1 kb	Distal (>10kb) Multiome HiCAR	1131
chr6:27,865,093–27,868,152	2.3 kb	Proximal (<10kb) Multiome	744
chr6:27,870,957–27,872,527	4.7 kb	Proximal (<10kb) Multiome	426
chr6:27,872,808–27,873,995	6.0 kb	Proximal (<10kb) Multiome	372
chr6:27,889,436–27,895,972	25.7 kb	Distal (>10kb) Multiome	1215
chr6:27,902,800–27,903,766	35.5 kb	Distal (>10kb) Multiome	891
chr6:28,079,998–28,081,441	212.6 kb	Distal (>10kb) Multiome	1054
chr6:28,104,510–28,105,291	237.3 kb	Distal (>10kb) Multiome	927
chr6:28,136,684–28,137,470	269.5 kb	Distal (>10kb) Multiome	1035
chr6:28,141,479–28,142,195	274.2 kb	Distal (>10kb) Multiome	1010

Genome Browser

Genomic view of the H1-5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.