The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Transcription factors with Perturb-seq knockdown data for GUK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GUK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GUK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:227,946,348–227,948,809 | 193.5 kb | Distal (>10kb) Multiome | 645 | |
| chr1:228,004,351–228,004,883 | 135.7 kb | Distal (>10kb) Multiome | 154 | |
| chr1:228,058,680–228,061,126 | 80.4 kb | Distal (>10kb) Multiome | 377 | |
| chr1:228,081,634–228,083,952 | 57.7 kb | Distal (>10kb) Multiome | 942 | |
| chr1:228,085,140–228,085,832 | 54.8 kb | Distal (>10kb) Multiome | 276 | |
| chr1:228,101,882–228,103,743 | 38.1 kb | Distal (>10kb) Multiome | 929 | |
| chr1:228,108,924–228,110,105 | 30.9 kb | Distal (>10kb) Multiome | 958 | |
| chr1:228,130,684–228,131,457 | 9.2 kb | Proximal (<10kb) Multiome | 488 | |
| chr1:228,139,579–228,140,870 | 159 bp | At TSS Multiome | 931 | |
| chr1:228,164,898–228,166,840 | 25.5 kb | Distal (>10kb) Multiome | 1011 | |
| chr1:228,174,477–228,174,893 | 34.4 kb | Distal (>10kb) Multiome | 254 | |
| chr1:228,212,247–228,214,390 | 73.4 kb | Distal (>10kb) Multiome | 604 | |
| chr1:228,275,524–228,276,595 | 135.8 kb | Distal (>10kb) Multiome | 428 | |
| chr1:228,378,133–228,379,597 | 238.4 kb | Distal (>10kb) Multiome | 515 | |
| chr1:228,406,106–228,407,568 | 266.7 kb | Distal (>10kb) Multiome | 753 | |
| chr1:228,416,050–228,416,929 | 276.2 kb | Distal (>10kb) Multiome | 279 |
Genomic view of the GUK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.