The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GTSE1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GTSE1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GTSE1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:46,013,459–46,014,306 | 283.1 kb | Distal (>10kb) Multiome | 814 | |
| chr22:46,035,443–46,036,717 | 261.0 kb | Distal (>10kb) Multiome | 735 | |
| chr22:46,061,373–46,062,193 | 235.1 kb | Distal (>10kb) Multiome | 257 | |
| chr22:46,070,177–46,072,638 | 225.8 kb | Distal (>10kb) Multiome | 557 | |
| chr22:46,116,470–46,116,929 | 180.2 kb | Distal (>10kb) Multiome | 471 | |
| chr22:46,149,521–46,151,433 | 146.5 kb | Distal (>10kb) Multiome | 562 | |
| chr22:46,201,176–46,201,774 | 95.3 kb | Distal (>10kb) Multiome | 124 | |
| chr22:46,249,918–46,250,866 | 46.5 kb | Distal (>10kb) Multiome | 831 | |
| chr22:46,262,531–46,263,383 | 34.0 kb | Distal (>10kb) Multiome | 169 | |
| chr22:46,267,542–46,268,277 | 28.9 kb | Distal (>10kb) Multiome | 725 | |
| chr22:46,296,072–46,297,498 | 85 bp | At TSS Multiome | 810 | |
| chr22:46,335,274–46,336,005 | 38.7 kb | Distal (>10kb) Multiome | 911 | |
| chr22:46,536,494–46,538,050 | 240.7 kb | Distal (>10kb) Multiome | 337 | |
| chr22:46,563,410–46,564,218 | 266.9 kb | Distal (>10kb) Multiome | 541 | |
| chr22:46,576,506–46,577,542 | 280.2 kb | Distal (>10kb) Multiome | 332 |
Genomic view of the GTSE1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.