GTPBP1
GTP binding protein 1 | GP-1, HSPC018

This gene is upregulated by interferon-gamma and encodes a protein that is a member of the AGP11/GTPBP1 family of GTP-binding proteins. A structurally similar protein has been found in mouse, where disruption of the gene for that protein had no observable phenotype. [provided by RefSeq, Jul 2008]

Member of: DE-10 DE-10.3
Biological processes 28 terms
GTP binding (GO:0005525)GTP binding (GO:0005525)GTP binding (GO:0005525)GTP metabolic process (GO:0046039)GTP metabolic process (GO:0046039)GTPase activity (GO:0003924)GTPase activity (GO:0003924)GTPase activity (GO:0003924)RNA binding (GO:0003723)RNA surveillance (GO:0071025)alpha-aminoacyl-tRNA binding (GO:1904678)alpha-aminoacyl-tRNA binding (GO:1904678)cytoplasm (GO:0005737)cytoplasmic exosome (RNase complex) (GO:0000177)cytoplasmic exosome (RNase complex) (GO:0000177)cytoplasmic translation (GO:0002181)cytosol (GO:0005829)cytosol (GO:0005829)immune response (GO:0006955)membrane (GO:0016020)positive regulation of mRNA catabolic process (GO:0061014)positive regulation of mRNA catabolic process (GO:0061014)protein binding (GO:0005515)signal transduction (GO:0007165)tRNA binding (GO:0000049)translation elongation factor activity (GO:0003746)translation elongation factor activity (GO:0003746)translational elongation (GO:0006414)
Expression (TPM)
GTPBP1 — as a Regulated Gene

TFs regulating GTPBP1 0 TFs

Transcription factors with Perturb-seq knockdown data for GTPBP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GTPBP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to GTPBP1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GTPBP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr22:38,455,555–38,456,345 249.7 kb Distal (>10kb) Multiome 403
chr22:38,461,291–38,461,848 244.1 kb Distal (>10kb) Multiome 595
chr22:38,505,466–38,506,961 199.2 kb Distal (>10kb) Multiome 889
chr22:38,569,664–38,571,256 135.4 kb Distal (>10kb) Multiome 559
chr22:38,655,982–38,657,104 49.3 kb Distal (>10kb) Multiome 698
chr22:38,681,730–38,682,262 23.8 kb Distal (>10kb) Multiome 947
chr22:38,700,377–38,701,744 4.8 kb Proximal (<10kb) Multiome 916
chr22:38,705,151–38,706,595 47 bp At TSS Multiome 821
chr22:38,712,530–38,712,793 6.8 kb Proximal (<10kb) 23
chr22:38,755,428–38,756,383 50.3 kb Distal (>10kb) Multiome 770
chr22:38,793,674–38,794,378 88.4 kb Distal (>10kb) Multiome 484
chr22:38,843,207–38,844,443 138.1 kb Distal (>10kb) Multiome 585
chr22:38,866,394–38,866,832 160.8 kb Distal (>10kb) Multiome 76
chr22:38,871,208–38,873,237 166.6 kb Distal (>10kb) Multiome 758

Genome Browser

Genomic view of the GTPBP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr22:38,445,555 – 38,883,237
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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