Enables RNA polymerase II general transcription initiation factor activity. Involved in transcription by RNA polymerase II. Located in cytosol and nucleoplasm. Part of transcription factor TFIID complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GTF2E1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GTF2E1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GTF2E1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:120,450,045–120,452,154 | 291.7 kb | Distal (>10kb) Multiome | 496 | |
| chr3:120,558,699–120,560,290 | 183.7 kb | Distal (>10kb) Multiome | 654 | |
| chr3:120,595,704–120,596,910 | 146.4 kb | Distal (>10kb) Multiome | 683 | |
| chr3:120,604,594–120,605,753 | 137.5 kb | Distal (>10kb) Multiome HiCAR | 62 | |
| chr3:120,622,775–120,623,611 | 119.6 kb | Distal (>10kb) Multiome | 221 | |
| chr3:120,677,217–120,678,016 | 65.3 kb | Distal (>10kb) Multiome | 75 | |
| chr3:120,719,201–120,720,128 | 23.1 kb | Distal (>10kb) Multiome | 147 | |
| chr3:120,741,971–120,743,234 | 172 bp | At TSS Multiome | 788 | |
| chr3:120,907,532–120,909,144 | 165.4 kb | Distal (>10kb) Multiome | 673 |
Genomic view of the GTF2E1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.