Predicted to act upstream of or within respiratory system development and response to lipopolysaccharide. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GSTCD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GSTCD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GSTCD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:105,472,920–105,474,489 | 234.8 kb | Distal (>10kb) Multiome HiCAR | 991 | |
| chr4:105,555,050–105,556,083 | 153.3 kb | Distal (>10kb) Multiome | 189 | |
| chr4:105,605,064–105,606,238 | 103.2 kb | Distal (>10kb) Multiome | 262 | |
| chr4:105,704,625–105,705,315 | 3.5 kb | Proximal (<10kb) | 7 | |
| chr4:105,708,104–105,709,494 | 32 bp | At TSS Multiome | 1158 | |
| chr4:105,894,711–105,896,958 | 186.4 kb | Distal (>10kb) Multiome | 578 |
Genomic view of the GSTCD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.