Enables voltage-gated monoatomic anion channel activity. Involved in intracellular pH reduction. Located in Golgi cisterna membrane and Golgi-associated vesicle membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GPR89A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPR89A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPR89A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:145,425,109–145,426,041 | 182.3 kb | Distal (>10kb) Multiome | 406 | |
| chr1:145,465,272–145,465,855 | 142.4 kb | Distal (>10kb) Multiome | 578 | |
| chr1:145,601,589–145,601,937 | 6.0 kb | Proximal (<10kb) | 5 | |
| chr1:145,607,803–145,608,364 | 28 bp | At TSS Multiome | 205 | |
| chr1:145,707,296–145,708,738 | 100.2 kb | Distal (>10kb) Multiome | 511 | |
| chr1:145,720,881–145,721,650 | 113.3 kb | Distal (>10kb) Multiome | 548 | |
| chr1:145,823,605–145,824,539 | 216.1 kb | Distal (>10kb) Multiome | 899 | |
| chr1:145,845,315–145,846,128 | 237.7 kb | Distal (>10kb) Multiome | 750 | |
| chr1:145,858,348–145,860,193 | 252.0 kb | Distal (>10kb) Multiome | 828 | |
| chr1:145,885,653–145,886,460 | 278.1 kb | Distal (>10kb) Multiome | 327 | |
| chr1:145,891,718–145,892,684 | 284.1 kb | Distal (>10kb) Multiome | 738 |
Genomic view of the GPR89A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.