The protein encoded by this gene belongs to the G protein-coupled receptor family, which contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. This is an orphan receptor, which displays significant level of constitutive activity. Association analysis shows preliminary evidence for the involvement of this gene in susceptibility to bipolar affective disorder and schizophrenia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]
Transcription factors with Perturb-seq knockdown data for GPR78. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPR78 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPR78, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:8,427,739–8,429,898 | 150.7 kb | Distal (>10kb) Multiome | 796 | |
| chr4:8,435,765–8,436,370 | 144.4 kb | Distal (>10kb) Multiome | 58 | |
| chr4:8,437,244–8,438,165 | 142.6 kb | Distal (>10kb) Multiome | 79 | |
| chr4:8,440,272–8,441,421 | 139.6 kb | Distal (>10kb) Multiome HiCAR | 843 | |
| chr4:8,559,567–8,561,304 | 20.5 kb | Distal (>10kb) Multiome HiCAR | 152 | |
| chr4:8,567,886–8,568,408 | 12.2 kb | Distal (>10kb) Multiome | 46 | |
| chr4:8,580,009–8,581,204 | 243 bp | At TSS Multiome | 591 | |
| chr4:8,592,223–8,593,386 | 12.3 kb | Distal (>10kb) Multiome HiCAR | 263 | |
| chr4:8,607,476–8,608,065 | 27.4 kb | Distal (>10kb) Multiome | 216 | |
| chr4:8,859,498–8,862,107 | 280.6 kb | Distal (>10kb) Multiome | 274 | |
| chr4:8,871,141–8,873,019 | 291.6 kb | Distal (>10kb) Multiome | 297 |
Genomic view of the GPR78 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.