Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in cilium. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GPR19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPR19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPR19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:12,349,790–12,350,566 | 334.3 kb | Distal (>10kb) Multiome HiCAR | 671 | |
| chr12:12,356,841–12,357,808 | 327.4 kb | Distal (>10kb) Multiome HiCAR | 912 | |
| chr12:12,561,525–12,563,261 | 121.7 kb | Distal (>10kb) Multiome HiCAR | 768 | |
| chr12:12,611,502–12,612,657 | 72.7 kb | Distal (>10kb) Multiome | 980 | |
| chr12:12,676,441–12,677,097 | 7.4 kb | Proximal (<10kb) | 70 | |
| chr12:12,684,299–12,685,064 | 219 bp | At TSS Multiome | 306 | |
| chr12:12,693,129–12,694,039 | 9.1 kb | Proximal (<10kb) Multiome HiCAR | 190 | |
| chr12:12,695,955–12,697,008 | 11.9 kb | Distal (>10kb) Multiome HiCAR | 568 | |
| chr12:12,704,663–12,704,918 | 8.5 kb | Proximal (<10kb) | 461 | |
| chr12:12,716,729–12,717,910 | 32.7 kb | Distal (>10kb) Multiome | 799 | |
| chr12:12,723,708–12,726,164 | 41.1 kb | Distal (>10kb) Multiome | 958 | |
| chr12:12,742,773–12,743,975 | 58.7 kb | Distal (>10kb) Multiome | 118 | |
| chr12:12,775,741–12,776,742 | 91.8 kb | Distal (>10kb) Multiome | 267 | |
| chr12:12,786,507–12,787,490 | 102.4 kb | Distal (>10kb) Multiome | 739 | |
| chr12:12,799,298–12,799,907 | 115.1 kb | Distal (>10kb) Multiome | 137 | |
| chr12:12,812,936–12,813,661 | 128.8 kb | Distal (>10kb) Multiome | 700 | |
| chr12:12,890,573–12,891,789 | 206.4 kb | Distal (>10kb) Multiome | 656 |
Genomic view of the GPR19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.