Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; and radial glial cell differentiation. Predicted to be located in ciliary membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GPR157. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPR157 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPR157, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:8,848,753–8,849,552 | 279.7 kb | Distal (>10kb) Multiome | 603 | |
| chr1:8,855,525–8,856,275 | 272.9 kb | Distal (>10kb) Multiome | 37 | |
| chr1:8,873,547–8,874,366 | 254.7 kb | Distal (>10kb) Multiome | 473 | |
| chr1:8,877,947–8,879,611 | 249.8 kb | Distal (>10kb) Multiome | 1144 | |
| chr1:9,128,169–9,129,971 | 599 bp | At TSS Multiome | 749 | |
| chr1:9,181,345–9,181,788 | 52.7 kb | Distal (>10kb) Multiome | 423 | |
| chr1:9,234,085–9,235,495 | 106.0 kb | Distal (>10kb) Multiome | 911 | |
| chr1:9,292,267–9,293,831 | 164.0 kb | Distal (>10kb) Multiome | 521 | |
| chr1:9,319,794–9,320,541 | 191.4 kb | Distal (>10kb) Multiome | 91 | |
| chr1:9,374,739–9,375,309 | 246.2 kb | Distal (>10kb) Multiome | 121 | |
| chr1:9,428,560–9,429,575 | 300.2 kb | Distal (>10kb) Multiome | 815 |
Genomic view of the GPR157 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.