This gene encodes a guanosine triphosphatase enzyme. The encoded protein may play a role in DNA repair and may function in activation of transcription. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
Transcription factors with Perturb-seq knockdown data for GPN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:27,356,094–27,357,596 | 272.1 kb | Distal (>10kb) Multiome | 1084 | |
| chr2:27,369,685–27,371,261 | 258.6 kb | Distal (>10kb) Multiome | 1096 | |
| chr2:27,380,026–27,381,202 | 248.3 kb | Distal (>10kb) Multiome | 821 | |
| chr2:27,408,972–27,410,056 | 219.4 kb | Distal (>10kb) Multiome HiCAR | 989 | |
| chr2:27,428,202–27,429,633 | 200.4 kb | Distal (>10kb) Multiome | 1013 | |
| chr2:27,441,811–27,442,884 | 186.7 kb | Distal (>10kb) Multiome | 380 | |
| chr2:27,489,334–27,490,205 | 139.2 kb | Distal (>10kb) Multiome HiCAR | 731 | |
| chr2:27,494,797–27,495,577 | 133.8 kb | Distal (>10kb) Multiome HiCAR | 380 | |
| chr2:27,517,085–27,517,958 | 111.5 kb | Distal (>10kb) Multiome | 130 | |
| chr2:27,582,572–27,583,317 | 46.1 kb | Distal (>10kb) Multiome | 843 | |
| chr2:27,628,534–27,629,380 | 40 bp | At TSS Multiome | 828 | |
| chr2:27,663,338–27,664,216 | 34.7 kb | Distal (>10kb) Multiome | 1035 | |
| chr2:27,681,105–27,682,049 | 52.6 kb | Distal (>10kb) Multiome | 85 | |
| chr2:27,715,293–27,715,981 | 86.9 kb | Distal (>10kb) Multiome | 346 | |
| chr2:27,735,279–27,736,049 | 106.6 kb | Distal (>10kb) Multiome | 395 | |
| chr2:27,752,465–27,753,359 | 123.8 kb | Distal (>10kb) Multiome | 577 | |
| chr2:27,771,346–27,772,271 | 142.7 kb | Distal (>10kb) Multiome | 941 | |
| chr2:27,889,901–27,891,358 | 261.6 kb | Distal (>10kb) Multiome | 1000 |
Genomic view of the GPN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.