This gene encodes a membrane glycoprotein that belongs to the proteolipid protein family. Proteolipid protein family members are expressed in most brain regions and are thought to be involved in cellular housekeeping functions such as membrane trafficking and cell-to-cell communication. This protein may also be involved in osteoblast differentiation. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are located on chromosomes Y and 22. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for GPM6B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPM6B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPM6B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:13,652,915–13,653,709 | 285.4 kb | Distal (>10kb) Multiome | 692 | |
| chrX:13,688,926–13,689,830 | 249.5 kb | Distal (>10kb) Multiome | 608 | |
| chrX:13,734,289–13,735,335 | 203.9 kb | Distal (>10kb) Multiome | 668 | |
| chrX:13,937,416–13,939,477 | 102 bp | At TSS Multiome | 380 | |
| chrX:14,029,131–14,030,229 | 91.2 kb | Distal (>10kb) Multiome HiCAR | 840 |
Genomic view of the GPM6B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.