The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and they have been implicated in the control of cell growth and cell division. The glypican encoded by this gene is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Mutations in this gene are associated with omodysplasia 1. [provided by RefSeq, Nov 2016]
Transcription factors with Perturb-seq knockdown data for GPC6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPC6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPC6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:93,215,855–93,216,888 | 10.5 kb | Distal (>10kb) Multiome | 170 | |
| chr13:93,224,343–93,224,864 | 1.9 kb | Proximal (<10kb) | 509 | |
| chr13:93,225,927–93,228,828 | 1.5 kb | Proximal (<10kb) Multiome | 832 | |
| chr13:93,228,961–93,229,634 | 2.2 kb | Proximal (<10kb) | 48 | |
| chr13:93,229,740–93,230,085 | 2.9 kb | Proximal (<10kb) | 30 | |
| chr13:93,233,657–93,234,429 | 6.9 kb | Proximal (<10kb) | 339 | |
| chr13:93,304,665–93,305,611 | 78.4 kb | Distal (>10kb) Multiome | 134 | |
| chr13:93,352,524–93,353,377 | 126.0 kb | Distal (>10kb) Multiome | 75 | |
| chr13:94,300,090–94,301,125 | 1073.8 kb | Distal (>10kb) Multiome HiCAR | 177 | |
| chr13:94,302,944–94,304,409 | 1076.6 kb | Distal (>10kb) Multiome HiCAR | 284 | |
| chr13:94,416,490–94,416,986 | 1189.9 kb | Distal (>10kb) Multiome HiCAR | 200 | |
| chr13:94,548,604–94,550,382 | 1322.8 kb | Distal (>10kb) Multiome HiCAR | 899 |
Genomic view of the GPC6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.