This gene was originally isolated by subtractive hybridization of cDNAs expressed in atherosclerotic plaques with a thrombus, and was found to be expressed only in vascular smooth muscle cells. However, a shorter splice variant was found to be more ubiquitously expressed. This protein is suggested to play a role in the development of atherosclerosis. Studies in mice suggest that it may also function as a GC-rich promoter-specific trans-activating transcription factor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Transcription factors with Perturb-seq knockdown data for GPBP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPBP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPBP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:56,909,110–56,910,601 | 264.2 kb | Distal (>10kb) Multiome HiCAR | 974 | |
| chr5:56,950,605–56,952,748 | 221.8 kb | Distal (>10kb) Multiome | 662 | |
| chr5:57,019,246–57,020,109 | 154.3 kb | Distal (>10kb) Multiome | 80 | |
| chr5:57,070,146–57,071,232 | 103.3 kb | Distal (>10kb) Multiome | 102 | |
| chr5:57,095,125–57,095,719 | 78.6 kb | Distal (>10kb) Multiome | 128 | |
| chr5:57,172,984–57,174,839 | 278 bp | At TSS Multiome | 992 |
Genomic view of the GPBP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.