Lysophosphatidic acid acyltransferases (EC 2.3.1.51) catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.[supplied by OMIM, Apr 2004]
Transcription factors with Perturb-seq knockdown data for GPAT4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPAT4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPAT4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:40,040,904–40,042,185 | 1536.7 kb | Distal (>10kb) Multiome HiCAR | 435 | |
| chr8:41,308,199–41,310,004 | 268.7 kb | Distal (>10kb) Multiome | 268 | |
| chr8:41,341,689–41,343,004 | 235.8 kb | Distal (>10kb) Multiome | 138 | |
| chr8:41,360,734–41,361,748 | 217.0 kb | Distal (>10kb) Multiome | 214 | |
| chr8:41,489,933–41,491,073 | 87.7 kb | Distal (>10kb) Multiome | 716 | |
| chr8:41,528,584–41,529,537 | 49.1 kb | Distal (>10kb) Multiome | 730 | |
| chr8:41,567,337–41,567,862 | 10.7 kb | Distal (>10kb) Multiome | 108 | |
| chr8:41,577,579–41,578,739 | 63 bp | At TSS Multiome | 755 | |
| chr8:41,646,199–41,646,780 | 68.3 kb | Distal (>10kb) Multiome | 132 | |
| chr8:41,653,451–41,654,479 | 75.9 kb | Distal (>10kb) Multiome | 235 | |
| chr8:41,701,707–41,702,358 | 123.7 kb | Distal (>10kb) Multiome | 481 | |
| chr8:41,766,804–41,768,073 | 189.2 kb | Distal (>10kb) Multiome | 304 | |
| chr8:41,791,812–41,792,404 | 214.0 kb | Distal (>10kb) Multiome | 574 | |
| chr8:41,818,697–41,819,374 | 240.8 kb | Distal (>10kb) Multiome | 577 | |
| chr8:41,828,115–41,829,096 | 250.3 kb | Distal (>10kb) Multiome | 805 |
Genomic view of the GPAT4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.