The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked, flattened membrane sacs referred to as cisternae. Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The golgins constitute a family of proteins which are localized to the Golgi. This gene encodes a golgin which structurally resembles its family member GOLGA2, suggesting that they may share a similar function. There are many similar copies of this gene on chromosome 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
Transcription factors with Perturb-seq knockdown data for GOLGA8A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GOLGA8A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GOLGA8A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:34,209,514–34,210,513 | 227.9 kb | Distal (>10kb) Multiome | 775 | |
| chr15:34,224,706–34,225,419 | 212.8 kb | Distal (>10kb) Multiome | 856 | |
| chr15:34,337,012–34,338,557 | 99.8 kb | Distal (>10kb) Multiome | 710 | |
| chr15:34,342,481–34,343,584 | 94.6 kb | Distal (>10kb) Multiome | 845 | |
| chr15:34,366,166–34,368,049 | 71.5 kb | Distal (>10kb) Multiome | 922 | |
| chr15:34,436,551–34,437,460 | 829 bp | At TSS Multiome | 165 | |
| chr15:34,437,715–34,438,115 | at TSS | At TSS | 551 | |
| chr15:34,494,295–34,495,393 | 57.0 kb | Distal (>10kb) Multiome | 115 | |
| chr15:34,514,176–34,515,283 | 77.1 kb | Distal (>10kb) Multiome | 588 | |
| chr15:34,582,613–34,584,384 | 146.0 kb | Distal (>10kb) Multiome | 711 | |
| chr15:34,721,776–34,722,400 | 284.2 kb | Distal (>10kb) Multiome | 275 |
Genomic view of the GOLGA8A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.