The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for GNL3L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GNL3L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GNL3L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:54,357,469–54,359,170 | 172.2 kb | Distal (>10kb) Multiome | 438 | |
| chrX:54,388,044–54,388,641 | 141.9 kb | Distal (>10kb) Multiome | 49 | |
| chrX:54,439,963–54,440,865 | 89.9 kb | Distal (>10kb) Multiome | 587 | |
| chrX:54,495,407–54,496,558 | 34.1 kb | Distal (>10kb) Multiome | 248 | |
| chrX:54,529,579–54,530,565 | 111 bp | At TSS Multiome | 641 | |
| chrX:54,639,123–54,640,128 | 109.5 kb | Distal (>10kb) Multiome | 686 | |
| chrX:54,807,568–54,809,334 | 278.5 kb | Distal (>10kb) Multiome | 567 |
Genomic view of the GNL3L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.