The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Transcription factors with Perturb-seq knockdown data for GNL3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GNL3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GNL3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:52,409,430–52,411,187 | 275.7 kb | Distal (>10kb) Multiome | 813 | |
| chr3:52,444,941–52,445,411 | 240.9 kb | Distal (>10kb) Multiome | 426 | |
| chr3:52,455,213–52,455,878 | 230.5 kb | Distal (>10kb) Multiome | 630 | |
| chr3:52,518,607–52,519,389 | 167.0 kb | Distal (>10kb) Multiome | 176 | |
| chr3:52,533,486–52,535,316 | 152.1 kb | Distal (>10kb) Multiome | 648 | |
| chr3:52,536,232–52,537,450 | 149.5 kb | Distal (>10kb) Multiome | 901 | |
| chr3:52,685,427–52,686,463 | 195 bp | At TSS Multiome | 933 | |
| chr3:52,705,495–52,706,415 | 20.0 kb | Distal (>10kb) Multiome | 862 | |
| chr3:52,714,354–52,715,301 | 28.7 kb | Distal (>10kb) Multiome | 224 | |
| chr3:52,770,467–52,771,332 | 84.9 kb | Distal (>10kb) Multiome | 788 | |
| chr3:52,897,094–52,897,995 | 211.6 kb | Distal (>10kb) Multiome | 474 |
Genomic view of the GNL3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.