Predicted to enable G-protein beta-subunit binding activity. Involved in negative regulation of cell growth. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GNG4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GNG4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GNG4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:235,367,126–235,367,788 | 282.4 kb | Distal (>10kb) Multiome | 851 | |
| chr1:235,503,729–235,505,713 | 145.2 kb | Distal (>10kb) Multiome | 1129 | |
| chr1:235,546,455–235,547,226 | 103.0 kb | Distal (>10kb) Multiome | 80 | |
| chr1:235,642,093–235,643,505 | 6.6 kb | Proximal (<10kb) Multiome | 410 | |
| chr1:235,648,124–235,648,863 | 920 bp | At TSS | 297 | |
| chr1:235,648,967–235,650,841 | 400 bp | At TSS Multiome | 689 | |
| chr1:235,650,998–235,651,264 | 1.2 kb | Proximal (<10kb) | 447 | |
| chr1:235,866,120–235,867,793 | 217.3 kb | Distal (>10kb) Multiome | 845 |
Genomic view of the GNG4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.